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what is lllt and how lllt work?

what is lllt ?

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What is LLLT Cold Laser Therapy?-In 1903, Dr. Nils Finsen was awarded a Nobel Prize for his contribution to the treatment of diseases, especially lupus vulgaris, with concentrated light radiation . In 1960, Professor Maiman TH built the first working red ruby laser , but it was not until 1967 when Mester E et al. was able to demonstrate the phenomenon of “laser bio stimulation” . In 1999, Whelan H et al. presented his work on the medical applications of light emitting diodes (LED) for use on the NASA space station . Subsequently over 400 Phase III randomized, double-blind, placebo-controlled trials have been published, with over 4000 laboratory studies of LLLT.

what is lllt
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lllt laser

A laser is a device that generates light through a process of optical amplification based on the stimulated emission of electromagnetic radiation. There are four main classes of lasers as defined by the International Engineering Consortium (IEC standard 60825.) These classes indicate potential danger the radiation is to the eye.

Class 1/1M – CD player
Class 2/2M – laser pointer
Class 3R/3B – LLLT and CD and DVD writers
Class 4 – Surgical laser

LLLT is the application of light (usually a low powered laser or LED typically power range of (10mW–500mW). Light with a wavelength in the red to near infrared region of the spectrum (660nm–905nm), is generally employed because these wavelengths have the ability to penetrate skin, and soft/hard tissues (Figure 2) and are proven in clinical trials to have a good effect on pain, inflammation and tissue repair. The power density (irradiance) is usually between 5W/cm2 and is applied to an injury or to a painful site for 30–60 seconds a few times a week for several weeks. The result is a reduction of inflammation, pain relief and accelerated tissue regeneration. In most cases the lasers/LEDs used for LLLT emit a divergent beam (not focused or collimated) because collimation is lost in tissue, but as a consequence ocular risks are also diminished over distance.

LLLT Cold Laser Therapy is a colloquial term for photobiomodulation or Low Level Laser Therapy (LLLT).

It is a light therapy using lasers or LEDs to improve tissue repair, reduce pain and inflammation wherever the beam is applied. Usually applied by a doctor, therapist or technician, treatments take about 10 minutes and should be applied two or more times a week.
Cold Laser has been used for many years on sports injuries, arthritic joints, neuropathic pain syndromes, back and neck pain. Over 400 randomised clinical trials have been published on Cold Laser, half of which are on pain.

LLLT Cold Laser Therapy, also known as low-level light therapy or therapeutic laser, is a wonderful, non-invasive way to speed healing and manage pain in dogs and cats. Actually, it’s even done for people, too! It was first cleared for use in Europe in the 1970’s, and finally cleared for use in the U.S. by the FDA in 2005. It’s very safe and has been very well-documented in hundreds of studies. We use K-Laser for our LLLT Cold Laser Therapy, and we have seen great results and lots of wagging tails as a result.

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how lllt work?

How LLLT work?-For low-power visible or near-infrared light to have an effect on a biologic system, the photon must be absorbed by electronic absorption bands belonging to a photon acceptor or chromophore (first law of photobiology) . A chromophore is a molecule (or portion of a molecule) which imparts a color to a compound (e.g. chlorophyll, hemoglobin, myoglobin, cytochrome c oxidase, other cytochromes, flavin, flavoproteins or porphyrins) . The “optical window” in a tissue describes a range of wavelengths where the penetration of light into tissue is maximized by employing red and near-infrared wavelengths . The optimum wavelength has been estimated to be around 810 nm. Mitochondria are “the cellular power plants” in our cells and as such they convert food molecules and oxygen into energy (ATP) by oxidative phosphorylation. It has been proposed that cytochrome c oxidase (COX) is the primary photo-acceptor for the red-NIR wavelength range in mammalian cells . Nitric oxide (NO) produced in mitochondria can inhibit respiration by binding to COX and displace oxygen especially in injured or hypoxic cells . It is proposed that LLLT can photo-dissociate NO from COX and reverse the mitochondrial inhibition of respiration due to excessive NO binding . The process of light mediated vasodilation was first described by RF Furchgott in 1968, and his research on the biological properties of nitric oxide eventually led to the award of a Nobel Prize in 1998 . LLLT is able to produce a shift in the overall cell redox potential in the direction of greater oxidation by increasing reactive oxygen species (ROS) and decreasing reactive nitrogen species (RNS). The long-term effects of LLLT are thought to be due to the activation of various transcription factors by the immediate chemical signaling molecules produce from mitochondrial stimulation by LLLT. The most important of these signaling molecules are thought to be ATP, cyclic-AMP, NO and ROS .

LLLT at low doses has been shown to enhance cell proliferation of fibroblasts , keratinocytes, endothelial cells and lymphocytes . The mechanism of proliferation is thought to result from photo-stimulation of the mitochondria leading to activation of signaling pathways and up regulation of transcription factors eventually giving rise to increases in growth factors . LLLT can enhance neovascularization, promote angiogenesis and increase collagen synthesis to aid in the healing of acute and chronic wounds . It has been observed in many studies, that LLLT exhibits a biphasic dose response curve, where by lower doses of light are more effective than much higher doses. These low doses of light have demonstrated the ability to heal skin, nerves, tendons, cartilage and bones.

LLLT is also known as Cold Laser Therapy. It uses laser light placed exactly over the area with pain. The device which is only flashlight size emits specific wavelengths of light to penetrate about 2 to 5 cm through the layers of the skin. A wavelength power of 830 or 940 nm has been reported to have a moderate effect on pain. But the studies are not completely conclusive as efficacy may depend on several other factors.

Class 3B for LLT

Not all types of lasers can be used to help chronic pain relief. The Food & Drugs Administration (FDA) classified medical laser treatment into 3 types: Class 4 Surgical Lasers, Class 3B Non-surgical Lasers, and Class 3A Low-Level Lasers. Class 3B and Class 3A are used in non-invasive treatments. In relation to chronic pain treatment, only Class 3B is able to penetrate and help in the healing process of deep tissue and joint pains.

Self-healing of the body

This laser therapy stimulates all types of cells.There are about 200 cell types in our body including the musculoskeletal cell system which is responsible for our movements and body support. When laser lights are directed to the pain areas, the muscle cells will start to heal and pain will be reduced. According to studies, a number of conditions merited from low laser treatment. It can be an alternative cure for rheumatoid arthritis, carpal tunnel syndrome, fibromyalgia, back pain, knee pain, tendonitis, neck pain and others. The first three diseases mentioned are autoimmune diseases just like polymyalgia rheumatica. There have also been testimonies and positive feedback about LLLT from PMR patients in social media.


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Gynaecology semiconductor Laser therapy device, LLLT, Pain relief and wound healing laser therapy device

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